UPB
insider transactionsUpstream Bio, Inc. — buys & sells by directors, officers and 10% owners A shareholder owning more than 10% of the company. Must report trades, but usually a weaker signal than an officer or director. (SEC Form 4).
Net shares · 365d
-32.4K
0 buy · 32.4K sell
Net value · 365d
-$566.7K
$0 in · $566.7K out
Sentiment · 365d
Net selling
0% buying · 100% selling
Open-market trades · 365d
15
0 buy · 32.4K sell
Net buy / sell volume
Not enough data to chart yet.
Tap or hover the chart for daily net volume. Green = net buying, red = net selling.
All transactions
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Grant·A
Director
$0
17.3K sh
Own New
-
Grant·A
Director
$0
17.3K sh
Own New
-
Sell·S
Chief Executive Officer
$12.8K
2.1K sh · $6.10
Own -3%
-
Sell·S
Chief Business Officer
$4.3K
700 sh · $6.10
Own -3%
-
Sell·S
Michael Gray KEY
CFO and COO
$5.2K
853 sh · $6.10
Own -3%
-
Sell·S
Chief Medical Officer
$5.5K
895 sh · $6.10
Own -3%
-
Sell·S
General Counsel
$2.9K
477 sh · $6.10
Own -3%
-
Grant·A
Director
$0
53.3K sh
Own New
-
Grant·A
Director
$0
17.1K sh
Own New
-
Grant·A
Director
$0
17.1K sh
Own New
-
Grant·A
Director
$0
17.1K sh
Own New
-
Grant·A
Director
$0
17.1K sh
Own New
-
Grant·A
Director
$0
17.1K sh
Own New
-
Grant·A
Director
$0
17.1K sh
Own New
-
Sell·S
Chief Medical Officer · 10b5-1
$31.9K
1.1K sh · $30.00
Own -2%
-
Sell·S
Chief Medical Officer · 10b5-1
$31.1K
1.0K sh · $31.05
Own -1%
-
Sell·S
Chief Executive Officer
$19.4K
2.1K sh · $9.29
Own -3%
-
Sell·S
Chief Business Officer
$6.5K
699 sh · $9.29
Own -3%
-
Sell·S
Michael Gray KEY
CFO and COO
$7.9K
852 sh · $9.29
Own -3%
-
Sell·S
Chief Medical Officer
$8.3K
894 sh · $9.29
Own -3%
-
Sell·S
General Counsel
$4.4K
475 sh · $9.29
Own -3%
-
Sell·S
Chief Medical Officer · 10b5-1
$300.0K
10.0K sh · $30.00
Own -13%
-
Grant·A
Chief Medical Officer
$0
24.2K sh
Own New
-
Grant·A
Chief Medical Officer
$0
26.5K sh
Own +50%
-
Other·F
Chief Medical Officer
$47.9K
2.1K sh · $23.22
Own -4%
-
Sell·S
Daniella Beckman KEY
Chief Financial Officer
$1.5K
113 sh · $12.90
Own -0%
-
Sell·S
Daniella Beckman KEY
Chief Financial Officer
$125.1K
10.2K sh · $12.26
Own -5%
-
Grant·A
Daniella Beckman KEY
Chief Financial Officer
$0
266.0K sh
Own New
-
Grant·A
Daniella Beckman KEY
Chief Financial Officer
$0
44.3K sh
Own +29%
-
Grant·A
Chief Executive Officer
$0
225.0K sh
Own New
-
Grant·A
Chief Executive Officer
$0
75.0K sh
Own New
-
Grant·A
Chief Business Officer
$0
75.0K sh
Own New
-
Grant·A
Chief Business Officer
$0
25.0K sh
Own New
-
Grant·A
Michael Gray KEY
CFO and COO
$0
91.5K sh
Own New
-
Grant·A
Michael Gray KEY
CFO and COO
$0
30.5K sh
Own New
-
Grant·A
Chief Medical Officer
$0
96.0K sh
Own New
-
Grant·A
Chief Medical Officer
$0
32.0K sh
Own +2024%
-
Grant·A
General Counsel
$0
51.0K sh
Own New
-
Grant·A
General Counsel
$0
17.0K sh
Own New
| Date▾ | Insider | Type | Shares | Value |
|---|---|---|---|---|
| Jun 17, 2026 | Marcella K. Ruddy | Grant A | 17.3K | $0 |
| Jun 17, 2026 | Harold Edward Fleming | Grant A | 17.3K | $0 |
| Jun 16, 2026 | Everett Rand Sutherland KEY | Sell S | 2.1K | $12.8K |
| Jun 16, 2026 | Adam Houghton | Sell S | 700 | $4.3K |
| Jun 16, 2026 | Michael Gray KEY | Sell S | 853 | $5.2K |
| Jun 16, 2026 | Aaron Deykin | Sell S | 895 | $5.5K |
| Jun 16, 2026 | Allison Ambrose | Sell S | 477 | $2.9K |
| Jun 11, 2026 | Daniella Beckman | Grant A | 53.3K | $0 |
| Jun 9, 2026 | Marcella K. Ruddy | Grant A | 17.1K | $0 |
| Jun 9, 2026 | Ronald C Renaud JR | Grant A | 17.1K | $0 |
| Jun 9, 2026 | Liam Ratcliffe | Grant A | 17.1K | $0 |
| Jun 9, 2026 | Harold Edward Fleming | Grant A | 17.1K | $0 |
| Jun 9, 2026 | Erez Chimovits | Grant A | 17.1K | $0 |
| Jun 9, 2026 | Daniella Beckman | Grant A | 17.1K | $0 |
| May 4, 2026 | Marcella K. Ruddy 10b5-1 | Sell S | 1.1K | $31.9K |
| Apr 1, 2026 | Marcella K. Ruddy 10b5-1 | Sell S | 1.0K | $31.1K |
| Mar 16, 2026 | Everett Rand Sutherland KEY | Sell S | 2.1K | $19.4K |
| Mar 16, 2026 | Adam Houghton | Sell S | 699 | $6.5K |
| Mar 16, 2026 | Michael Gray KEY | Sell S | 852 | $7.9K |
| Mar 16, 2026 | Aaron Deykin | Sell S | 894 | $8.3K |
| Mar 16, 2026 | Allison Ambrose | Sell S | 475 | $4.4K |
| Mar 6, 2026 | Marcella K. Ruddy 10b5-1 | Sell S | 10.0K | $300.0K |
| Mar 4, 2026 | Marcella K. Ruddy | Grant A | 24.2K | $0 |
| Mar 4, 2026 | Marcella K. Ruddy | Grant A | 26.5K | $0 |
| Feb 4, 2026 | Marcella K. Ruddy | Other F | 2.1K | $47.9K |
| Feb 3, 2026 | Daniella Beckman KEY | Sell S | 113 | $1.5K |
| Feb 3, 2026 | Daniella Beckman KEY | Sell S | 10.2K | $125.1K |
| Feb 2, 2026 | Daniella Beckman KEY | Grant A | 266.0K | $0 |
| Feb 2, 2026 | Daniella Beckman KEY | Grant A | 44.3K | $0 |
| Jan 2, 2026 | Everett Rand Sutherland KEY | Grant A | 225.0K | $0 |
| Jan 2, 2026 | Everett Rand Sutherland KEY | Grant A | 75.0K | $0 |
| Jan 2, 2026 | Adam Houghton | Grant A | 75.0K | $0 |
| Jan 2, 2026 | Adam Houghton | Grant A | 25.0K | $0 |
| Jan 2, 2026 | Michael Gray KEY | Grant A | 91.5K | $0 |
| Jan 2, 2026 | Michael Gray KEY | Grant A | 30.5K | $0 |
| Jan 2, 2026 | Aaron Deykin | Grant A | 96.0K | $0 |
| Jan 2, 2026 | Aaron Deykin | Grant A | 32.0K | $0 |
| Jan 2, 2026 | Allison Ambrose | Grant A | 51.0K | $0 |
| Jan 2, 2026 | Allison Ambrose | Grant A | 17.0K | $0 |
About UPB insider trading
This page tracks insider transactions for Upstream Bio, Inc. (UPB) reported to the U.S. Securities and Exchange Commission on Form 4. Corporate insiders — directors, executive officers and beneficial owners of more than 10% of the stock — must disclose their trades within two business days. Open-market purchases (code P) and sales (code S) made at the insider's discretion are the most-watched opportunistic signals, while awards (A), option exercises (M) and tax-withholding (F) reflect compensation rather than conviction. Trades marked 10b5-1 were made under a pre-arranged plan and are considered routine. A cluster buy — several insiders buying within a short window — is historically a stronger bullish indicator than any single trade.