IONS
insider transactionsIONIS PHARMACEUTICALS INC — buys & sells by directors, officers and 10% owners A shareholder owning more than 10% of the company. Must report trades, but usually a weaker signal than an officer or director. (SEC Form 4).
Net shares · 365d
-1.3M
0 buy · 1.3M sell
Net value · 365d
-$98.9M
$0 in · $98.9M out
Sentiment · 365d
Net selling
0% buying · 100% selling
Open-market trades · 365d
86
0 buy · 1.3M sell
Net buy / sell volume
Not enough data to chart yet.
Tap or hover the chart for daily net volume. Green = net buying, red = net selling.
All transactions
-
Exercise·M
Director · 10b5-1
$0
8.0K sh
Own New
-
Sell·S
Director · 10b5-1
$587.9K
8.0K sh · $73.49
Own -5%
-
Exercise·M
Director · 10b5-1
$195.4K
8.0K sh · $24.42
Own +5%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$0
21.0K sh
Own New
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$0
8.0K sh
Own +61%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$0
19.9K sh
Own New
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$0
12.0K sh
Own New
-
Sell·S
EVP, Chief Development Officer · 10b5-1
$1.5M
19.8K sh · $74.05
Own -47%
-
Sell·S
EVP, Chief Development Officer · 10b5-1
$3.0M
41.0K sh · $73.09
Own -49%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$1.1M
19.9K sh · $56.78
Own +31%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$391.2K
12.0K sh · $32.60
Own +23%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$1.3M
21.0K sh · $60.89
Own +69%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$484.1K
8.0K sh · $60.89
Own +35%
-
Grant·A
Director
$0
10.8K sh
Own New
-
Grant·A
Director
$0
10.8K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
8.0K sh
Own New
-
Sell·S
Director · 10b5-1
$605.4K
8.0K sh · $75.67
Own -5%
-
Exercise·M
Director · 10b5-1
$195.4K
8.0K sh · $24.42
Own +5%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$0
3.2K sh
Own +10%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$253.3K
3.2K sh · $78.68
Own -1%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$105.0K
3.2K sh · $32.60
Own +1%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$0
1.3K sh
Own +4%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$102.7K
1.3K sh · $78.01
Own -1%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$42.9K
1.3K sh · $32.60
Own +1%
-
Exercise·M
Director · 10b5-1
$0
16.0K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
10.3K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
12.0K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
11.0K sh
Own New
-
Sell·S
Director · 10b5-1
$1.3M
17.8K sh · $75.58
Own -33%
-
Sell·S
Director · 10b5-1
$4.5M
59.5K sh · $74.90
Own -52%
-
Exercise·M
Director · 10b5-1
$1.0M
16.0K sh · $64.80
Own +16%
-
Exercise·M
Director · 10b5-1
$722.4K
12.0K sh · $60.20
Own +14%
-
Exercise·M
Director · 10b5-1
$686.1K
16.0K sh · $42.88
Own +23%
-
Exercise·M
Director · 10b5-1
$424.0K
10.3K sh · $41.08
Own +17%
-
Exercise·M
Director · 10b5-1
$480.6K
12.0K sh · $40.05
Own +25%
-
Exercise·M
Director · 10b5-1
$417.4K
11.0K sh · $38.06
Own +30%
-
Exercise·M
Director · 10b5-1
$0
10.1K sh
Own New
-
Sell·S
Director · 10b5-1
$106.5K
1.4K sh · $74.45
Own -11%
-
Sell·S
Director · 10b5-1
$636.7K
8.7K sh · $73.35
Own -41%
-
Exercise·M
Director · 10b5-1
$476.3K
10.1K sh · $47.11
Own +92%
-
Sell·S
EVP, Chief Business Officer · 10b5-1
$116.7K
1.6K sh · $71.79
Own -3%
-
Sell·S
EVP, Chf GL Pdt Str Ofcr
$368.5K
4.9K sh · $75.17
Own -17%
-
Sell·S
EVP, Corp and Development Ops
$73.0K
973 sh · $75.04
Own -1%
-
Sell·S
EVP, Chief Business Officer
$419.0K
5.6K sh · $74.56
Own -11%
-
Sell·S
Director · 10b5-1
$41.1K
534 sh · $76.97
Own -1%
-
Sell·S
Director · 10b5-1
$340.3K
4.5K sh · $76.19
Own -8%
-
Exercise·M
EVP, Chf GL Pdt Str Ofcr
$0
12.2K sh
Own +20%
-
Exercise·M
EVP, Chf GL Pdt Str Ofcr
$0
12.2K sh
Own +75%
-
Exercise·M
EVP, Corp and Development Ops
$0
1.9K sh
Own +4%
-
Exercise·M
EVP, Corp and Development Ops
$0
1.9K sh
Own +3%
-
Exercise·M
EVP, Chief Business Officer
$0
10.8K sh
Own +29%
-
Exercise·M
EVP, Chief Business Officer
$0
10.8K sh
Own +26%
-
Other·D
Director
—
5.5K sh
Own -100%
-
Other·D
Director
—
4.5K sh
Own -100%
-
Other·D
Director
—
4.2K sh
Own -100%
-
Other·D
Director
—
5.3K sh
Own -100%
-
Other·D
Director
—
5.1K sh
Own -100%
-
Other·D
Director
—
7.3K sh
Own -100%
-
Other·D
Director
—
6.5K sh
Own -100%
-
Other·D
Director
—
2.0K sh
Own -100%
-
Other·D
Director
—
16.1K sh
Own -100%
-
Sell·S
EVP, Chief Human Resources Ofc · 10b5-1
$458.6K
6.2K sh · $74.05
Own -27%
-
Exercise·M
Director · 10b5-1
$0
10.3K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
12.0K sh
Own New
-
Sell·S
Director · 10b5-1
$168.3K
2.2K sh · $75.95
Own -17%
-
Sell·S
Director · 10b5-1
$1.5M
20.1K sh · $75.50
Own -60%
-
Exercise·M
Director · 10b5-1
$424.0K
10.3K sh · $41.08
Own +45%
-
Exercise·M
Director · 10b5-1
$456.7K
12.0K sh · $38.06
Own +109%
-
Sell·S
EVP, Chf Clinical Develop Ofcr · 10b5-1
$412.5K
5.8K sh · $70.97
Own -8%
-
Sell·S
EVP, Finance & CFO · 10b5-1
$744.7K
10.2K sh · $73.21
Own -11%
-
Exercise·M
EVP, Finance & CFO · 10b5-1
$0
60.3K sh
Own New
-
Exercise·M
EVP, Finance & CFO · 10b5-1
$0
61.0K sh
Own New
-
Exercise·M
EVP, Finance & CFO · 10b5-1
$0
20.5K sh
Own New
-
Exercise·M
EVP, Finance & CFO · 10b5-1
$0
33.1K sh
Own New
-
Sell·S
EVP, Finance & CFO · 10b5-1
$686.9K
9.4K sh · $72.77
Own -9%
-
Sell·S
EVP, Finance & CFO · 10b5-1
$14.9M
205.6K sh · $72.38
Own -67%
-
Exercise·M
EVP, Finance & CFO · 10b5-1
$771.9K
20.5K sh · $37.58
Own +7%
-
Exercise·M
EVP, Finance & CFO · 10b5-1
$1.1M
33.1K sh · $32.60
Own +13%
-
Exercise·M
EVP, Finance & CFO · 10b5-1
$3.5M
61.0K sh · $56.78
Own +32%
-
Exercise·M
EVP, Finance & CFO · 10b5-1
$3.7M
60.3K sh · $60.89
Own +45%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$0
34.1K sh
Own New
-
Sell·S
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$1.3M
17.6K sh · $76.34
Own -7%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$1.2M
16.5K sh · $75.47
Own -6%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$2.1M
34.1K sh · $60.89
Own +14%
-
Exercise·M
EVP, Chf GL Pdt Str Ofcr · 10b5-1
$0
32.6K sh
Own New
-
Exercise·M
EVP, Chf GL Pdt Str Ofcr · 10b5-1
$0
4.7K sh
Own +50%
-
Exercise·M
EVP, Chf GL Pdt Str Ofcr · 10b5-1
$162.2K
4.7K sh · $34.69
Own +40%
-
Sell·S
EVP, Chf GL Pdt Str Ofcr · 10b5-1
$1.2M
16.1K sh · $76.30
Own -58%
-
Sell·S
EVP, Chf GL Pdt Str Ofcr · 10b5-1
$1.6M
21.2K sh · $75.50
Own -43%
-
Exercise·M
EVP, Chf GL Pdt Str Ofcr · 10b5-1
$1.5M
32.6K sh · $46.10
Own +199%
-
Sell·S
EVP CLO & General Counsel · 10b5-1
$763.7K
10.1K sh · $75.25
Own -14%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$0
73.5K sh
Own New
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$0
40.8K sh
Own +61%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$127.3K
1.7K sh · $75.58
Own -1%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$8.9M
117.6K sh · $75.26
Own -32%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$547.1K
7.4K sh · $74.11
Own -2%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$4.5M
73.5K sh · $60.89
Own +25%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$2.5M
40.8K sh · $60.89
Own +16%
-
Exercise·M
Director · 10b5-1
$0
200 sh
Own +2%
-
Sell·S
Director · 10b5-1
$16.0K
200 sh · $80.00
Own -1%
-
Exercise·M
Director · 10b5-1
$7.6K
200 sh · $38.06
Own +1%
-
Exercise·M
EVP, Chief Business Officer · 10b5-1
$0
238 sh
Own +7%
-
Exercise·M
EVP, Chief Business Officer · 10b5-1
$0
201 sh
Own +13%
-
Sell·S
EVP, Chief Business Officer · 10b5-1
$16.1K
201 sh · $80.00
Own -4%
-
Exercise·M
EVP, Chief Business Officer · 10b5-1
$6.6K
201 sh · $32.60
Own +5%
-
Sell·S
EVP, Chief Business Officer · 10b5-1
$19.0K
238 sh · $80.00
Own -5%
-
Exercise·M
EVP, Chief Business Officer · 10b5-1
$13.5K
238 sh · $56.78
Own +5%
-
Exercise·M
Director · 10b5-1
$0
832 sh
Own +8%
-
Sell·S
Director · 10b5-1
$66.8K
832 sh · $80.33
Own -2%
-
Exercise·M
Director · 10b5-1
$31.7K
832 sh · $38.06
Own +2%
-
Exercise·M
Director · 10b5-1
$0
4.0K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
12.0K sh
Own New
-
Sell·S
Director · 10b5-1
$81.8K
1.0K sh · $80.82
Own -8%
-
Sell·S
Director · 10b5-1
$543.5K
6.8K sh · $80.00
Own -36%
-
Sell·S
Director · 10b5-1
$1.1M
13.5K sh · $79.17
Own -42%
-
Exercise·M
Director · 10b5-1
$171.5K
4.0K sh · $42.88
Own +14%
-
Exercise·M
Director · 10b5-1
$480.6K
12.0K sh · $40.05
Own +73%
-
Exercise·M
Director · 10b5-1
$0
10.3K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
18.0K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
12.0K sh
Own New
-
Sell·S
Director · 10b5-1
$81.2K
1.0K sh · $80.80
Own -21%
-
Sell·S
Director · 10b5-1
$1.2M
14.6K sh · $79.88
Own -75%
-
Sell·S
Director · 10b5-1
$3.1M
39.3K sh · $79.11
Own -67%
-
Exercise·M
Director · 10b5-1
$720.9K
18.0K sh · $40.05
Own +44%
-
Exercise·M
Director · 10b5-1
$456.7K
12.0K sh · $38.06
Own +42%
-
Exercise·M
Director · 10b5-1
$424.0K
10.3K sh · $41.08
Own +56%
-
Exercise·M
EVP, Chief Human Resources Ofc · 10b5-1
$0
385 sh
Own +5%
-
Exercise·M
EVP, Chief Human Resources Ofc · 10b5-1
$0
3.8K sh
Own +50%
-
Exercise·M
EVP, Chief Human Resources Ofc · 10b5-1
$0
3.5K sh
Own +157%
-
Exercise·M
EVP, Chief Human Resources Ofc · 10b5-1
$0
5.5K sh
Own +50%
-
Exercise·M
EVP, Chief Human Resources Ofc · 10b5-1
$0
7.0K sh
Own New
-
Sell·S
EVP, Chief Human Resources Ofc · 10b5-1
$61.0K
755 sh · $80.84
Own -3%
-
Sell·S
EVP, Chief Human Resources Ofc · 10b5-1
$402.4K
5.0K sh · $80.00
Own -18%
-
Sell·S
EVP, Chief Human Resources Ofc · 10b5-1
$1.1M
14.3K sh · $79.12
Own -34%
-
Exercise·M
EVP, Chief Human Resources Ofc · 10b5-1
$20.4K
385 sh · $52.87
Own +1%
-
Exercise·M
EVP, Chief Human Resources Ofc · 10b5-1
$226.6K
7.0K sh · $32.60
Own +20%
-
Exercise·M
EVP, Chief Human Resources Ofc · 10b5-1
$190.8K
5.5K sh · $34.69
Own +18%
-
Exercise·M
EVP, Chief Human Resources Ofc · 10b5-1
$153.6K
3.8K sh · $40.85
Own +14%
-
Exercise·M
EVP, Chief Human Resources Ofc · 10b5-1
$131.9K
3.5K sh · $37.58
Own +16%
-
Exercise·M
EVP, Chief Business Officer · 10b5-1
$0
820 sh
Own +25%
-
Exercise·M
EVP, Chief Business Officer · 10b5-1
$0
879 sh
Own +81%
-
Sell·S
EVP, Chief Business Officer · 10b5-1
$2.9K
36 sh · $81.01
Own -1%
-
Sell·S
EVP, Chief Business Officer · 10b5-1
$167.9K
2.1K sh · $80.41
Own -32%
-
Exercise·M
EVP, Chief Business Officer · 10b5-1
$28.7K
879 sh · $32.60
Own +16%
-
Exercise·M
EVP, Chief Business Officer · 10b5-1
$46.6K
820 sh · $56.78
Own +17%
-
Sell·S
EVP, Chief Business Officer · 10b5-1
$325.1K
4.1K sh · $79.36
Own -9%
-
Exercise·M
EVP, Chief Scientific Officer · 10b5-1
$0
48.6K sh
Own New
-
Exercise·M
EVP, Chief Scientific Officer · 10b5-1
$0
16.5K sh
Own New
-
Sell·S
EVP, Chief Scientific Officer · 10b5-1
$64.8K
802 sh · $80.76
Own -1%
-
Sell·S
EVP, Chief Scientific Officer · 10b5-1
$1.0M
12.7K sh · $79.88
Own -13%
-
Sell·S
EVP, Chief Scientific Officer · 10b5-1
$5.7M
71.6K sh · $79.10
Own -43%
-
Exercise·M
EVP, Chief Scientific Officer · 10b5-1
$3.0M
48.6K sh · $60.89
Own +42%
-
Exercise·M
EVP, Chief Scientific Officer · 10b5-1
$536.7K
16.5K sh · $32.60
Own +16%
-
Other·J
EVP Research
$12.5K
256 sh · $48.87
-
Other·J
EVP CLO & General Counsel
$18.4K
376 sh · $48.87
-
Other·J
Brett P Monia KEY
Chief Executive Officer
$23.7K
484 sh · $48.87
-
Other·J
EVP, Corp and Development Ops
$17.2K
351 sh · $48.87
-
Other·J
EVP, Chief Scientific Officer
$12.8K
261 sh · $48.87
-
Grant·A
Director
—
3.2K sh
Own +25%
-
Sell·S
EVP Research · 10b5-1
$509.4K
6.2K sh · $82.07
Own -16%
-
Sell·S
EVP Research · 10b5-1
$769.5K
9.4K sh · $81.56
Own -20%
-
Sell·S
Director · 10b5-1
$413.6K
5.0K sh · $82.72
Own -8%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$2.5M
29.4K sh · $85.79
Own -10%
-
Exercise·M
EVP, Chief Scientific Officer · 10b5-1
$0
48.6K sh
Own New
-
Exercise·M
EVP, Chief Scientific Officer · 10b5-1
$0
16.5K sh
Own New
-
Sell·S
EVP, Chief Scientific Officer · 10b5-1
$1.4M
16.5K sh · $83.03
Own -17%
-
Exercise·M
EVP, Chief Scientific Officer · 10b5-1
$536.7K
16.5K sh · $32.60
Own +21%
-
Sell·S
EVP, Chief Scientific Officer · 10b5-1
$4.0M
48.6K sh · $83.03
Own -38%
-
Exercise·M
EVP, Chief Scientific Officer · 10b5-1
$3.0M
48.6K sh · $60.89
Own +61%
-
Sell·S
EVP, Chief Scientific Officer · 10b5-1
$1.7M
20.0K sh · $82.60
Own -20%
-
Other·J
EVP, Chief Scientific Officer
$0
0 sh
-
Sell·S
EVP Research
$512.4K
6.2K sh · $82.93
Own -11%
-
Sell·S
EVP, Chf Clinical Develop Ofcr
$515.6K
6.2K sh · $83.45
Own -8%
-
Sell·S
EVP CLO & General Counsel
$516.2K
6.2K sh · $83.53
Own -8%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer
$5.2M
63.0K sh · $82.72
Own -18%
-
Sell·S
EVP, Finance & CFO
$581.7K
7.0K sh · $83.24
Own -5%
-
Sell·S
EVP, Corp and Development Ops
$513.0K
6.2K sh · $83.03
Own -9%
-
Sell·S
EVP, Chief Business Officer
$439.4K
5.3K sh · $82.96
Own -10%
-
Sell·S
EVP, Chief Scientific Officer
$488.1K
5.9K sh · $82.95
Own -6%
-
Grant·A
EVP Research
$0
12.0K sh
Own +29%
-
Grant·A
EVP, Chf Clinical Develop Ofcr
$0
12.0K sh
Own +19%
-
Grant·A
EVP CLO & General Counsel
$0
12.0K sh
Own +18%
-
Grant·A
Brett P Monia KEY
Chief Executive Officer
$0
122.2K sh
Own +54%
-
Grant·A
EVP, Finance & CFO
$0
13.6K sh
Own +11%
-
Grant·A
EVP, Corp and Development Ops
$0
12.0K sh
Own +20%
-
Grant·A
EVP, Chief Business Officer
$0
10.3K sh
Own +25%
-
Grant·A
EVP, Chief Scientific Officer
$0
11.4K sh
Own +12%
-
Sell·S
EVP, Chief Human Resources Ofc · 10b5-1
$323.5K
4.0K sh · $81.34
Own -15%
-
Sell·S
EVP Research
$3.7K
49 sh · $75.97
Own -13%
-
Sell·S
EVP Research
$744.7K
9.9K sh · $75.34
Own -19%
-
Sell·S
EVP, Chf Clinical Develop Ofcr
$703.1K
9.3K sh · $75.59
Own -13%
-
Sell·S
EVP CLO & General Counsel
$697.0K
9.2K sh · $75.84
Own -12%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer
$3.3M
44.0K sh · $74.82
Own -16%
-
Sell·S
EVP, Chief Development Officer
$313.3K
4.1K sh · $75.66
Own -22%
-
Sell·S
EVP, Chf GL Pdt Str Ofcr
$138.5K
1.8K sh · $75.96
Own -10%
-
Sell·S
EVP, Finance & CFO
$972.0K
12.9K sh · $75.22
Own -9%
-
Sell·S
EVP, Chief Human Resources Ofc
$634.4K
8.4K sh · $75.95
Own -24%
-
Sell·S
EVP, Corp and Development Ops
$636.9K
8.5K sh · $75.11
Own -12%
-
Sell·S
EVP, Chief Business Officer
$87.1K
1.1K sh · $75.78
Own -19%
-
Sell·S
EVP, Chief Business Officer
$523.2K
6.9K sh · $75.75
Own -15%
| Date▾ | Insider | Type | Shares | Value |
|---|---|---|---|---|
| Jun 15, 2026 | BERTHELSEN SPENCER R 10b5-1 | Exercise M | 8.0K | $0 |
| Jun 15, 2026 | BERTHELSEN SPENCER R 10b5-1 | Sell S | 8.0K | $587.9K |
| Jun 15, 2026 | BERTHELSEN SPENCER R 10b5-1 | Exercise M | 8.0K | $195.4K |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 21.0K | $0 |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 8.0K | $0 |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 19.9K | $0 |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 12.0K | $0 |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Sell S | 19.8K | $1.5M |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Sell S | 41.0K | $3.0M |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 19.9K | $1.1M |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 12.0K | $391.2K |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 21.0K | $1.3M |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 8.0K | $484.1K |
| Jun 4, 2026 | Peter N Reikes | Grant A | 10.8K | $0 |
| Jun 4, 2026 | Ludwig Hantson | Grant A | 10.8K | $0 |
| Jun 1, 2026 | BERTHELSEN SPENCER R 10b5-1 | Exercise M | 8.0K | $0 |
| Jun 1, 2026 | BERTHELSEN SPENCER R 10b5-1 | Sell S | 8.0K | $605.4K |
| Jun 1, 2026 | BERTHELSEN SPENCER R 10b5-1 | Exercise M | 8.0K | $195.4K |
| May 14, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 3.2K | $0 |
| May 14, 2026 | Brett P Monia KEY 10b5-1 | Sell S | 3.2K | $253.3K |
| May 14, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 3.2K | $105.0K |
| May 13, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 1.3K | $0 |
| May 13, 2026 | Brett P Monia KEY 10b5-1 | Sell S | 1.3K | $102.7K |
| May 13, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 1.3K | $42.9K |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 16.0K | $0 |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 10.3K | $0 |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 12.0K | $0 |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 11.0K | $0 |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Sell S | 17.8K | $1.3M |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Sell S | 59.5K | $4.5M |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 16.0K | $1.0M |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 12.0K | $722.4K |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 16.0K | $686.1K |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 10.3K | $424.0K |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 12.0K | $480.6K |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 11.0K | $417.4K |
| May 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 10.1K | $0 |
| May 1, 2026 | Joseph Klein III 10b5-1 | Sell S | 1.4K | $106.5K |
| May 1, 2026 | Joseph Klein III 10b5-1 | Sell S | 8.7K | $636.7K |
| May 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 10.1K | $476.3K |
| Apr 28, 2026 | Joseph Baroldi 10b5-1 | Sell S | 1.6K | $116.7K |
| Apr 16, 2026 | Kyle Jenne | Sell S | 4.9K | $368.5K |
| Apr 16, 2026 | Brian Birchler | Sell S | 973 | $73.0K |
| Apr 16, 2026 | Joseph Baroldi | Sell S | 5.6K | $419.0K |
| Apr 15, 2026 | Lynne B Parshall 10b5-1 | Sell S | 534 | $41.1K |
| Apr 15, 2026 | Lynne B Parshall 10b5-1 | Sell S | 4.5K | $340.3K |
| Apr 15, 2026 | Kyle Jenne | Exercise M | 12.2K | $0 |
| Apr 15, 2026 | Kyle Jenne | Exercise M | 12.2K | $0 |
| Apr 15, 2026 | Brian Birchler | Exercise M | 1.9K | $0 |
| Apr 15, 2026 | Brian Birchler | Exercise M | 1.9K | $0 |
| Apr 15, 2026 | Joseph Baroldi | Exercise M | 10.8K | $0 |
| Apr 15, 2026 | Joseph Baroldi | Exercise M | 10.8K | $0 |
| Apr 7, 2026 | Ludwig Hantson | Other D | 5.5K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 4.5K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 4.2K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 5.3K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 5.1K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 7.3K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 6.5K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 2.0K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 16.1K | — |
| Apr 2, 2026 | Shannon L. Devers 10b5-1 | Sell S | 6.2K | $458.6K |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 10.3K | $0 |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 12.0K | $0 |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Sell S | 2.2K | $168.3K |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Sell S | 20.1K | $1.5M |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 10.3K | $424.0K |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 12.0K | $456.7K |
| Mar 19, 2026 | Eugene Schneider 10b5-1 | Sell S | 5.8K | $412.5K |
| Mar 17, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Sell S | 10.2K | $744.7K |
| Mar 16, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Exercise M | 60.3K | $0 |
| Mar 16, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Exercise M | 61.0K | $0 |
| Mar 16, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Exercise M | 20.5K | $0 |
| Mar 16, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Exercise M | 33.1K | $0 |
| Mar 16, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Sell S | 9.4K | $686.9K |
| Mar 16, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Sell S | 205.6K | $14.9M |
| Mar 16, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Exercise M | 20.5K | $771.9K |
| Mar 16, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Exercise M | 33.1K | $1.1M |
| Mar 16, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Exercise M | 61.0K | $3.5M |
| Mar 16, 2026 | HOUGEN ELIZABETH L KEY 10b5-1 | Exercise M | 60.3K | $3.7M |
| Mar 10, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 34.1K | $0 |
| Mar 10, 2026 | Brett P Monia KEY 10b5-1 | Sell S | 17.6K | $1.3M |
| Mar 10, 2026 | Brett P Monia KEY 10b5-1 | Sell S | 16.5K | $1.2M |
| Mar 10, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 34.1K | $2.1M |
| Mar 10, 2026 | Kyle Jenne 10b5-1 | Exercise M | 32.6K | $0 |
| Mar 10, 2026 | Kyle Jenne 10b5-1 | Exercise M | 4.7K | $0 |
| Mar 10, 2026 | Kyle Jenne 10b5-1 | Exercise M | 4.7K | $162.2K |
| Mar 10, 2026 | Kyle Jenne 10b5-1 | Sell S | 16.1K | $1.2M |
| Mar 10, 2026 | Kyle Jenne 10b5-1 | Sell S | 21.2K | $1.6M |
| Mar 10, 2026 | Kyle Jenne 10b5-1 | Exercise M | 32.6K | $1.5M |
| Mar 9, 2026 | O'NEIL PATRICK R. 10b5-1 | Sell S | 10.1K | $763.7K |
| Mar 9, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 73.5K | $0 |
| Mar 9, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 40.8K | $0 |
| Mar 9, 2026 | Brett P Monia KEY 10b5-1 | Sell S | 1.7K | $127.3K |
| Mar 9, 2026 | Brett P Monia KEY 10b5-1 | Sell S | 117.6K | $8.9M |
| Mar 9, 2026 | Brett P Monia KEY 10b5-1 | Sell S | 7.4K | $547.1K |
| Mar 9, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 73.5K | $4.5M |
| Mar 9, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 40.8K | $2.5M |
| Mar 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 200 | $0 |
| Mar 4, 2026 | Joseph Loscalzo 10b5-1 | Sell S | 200 | $16.0K |
| Mar 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 200 | $7.6K |
| Mar 4, 2026 | Joseph Baroldi 10b5-1 | Exercise M | 238 | $0 |
| Mar 4, 2026 | Joseph Baroldi 10b5-1 | Exercise M | 201 | $0 |
| Mar 4, 2026 | Joseph Baroldi 10b5-1 | Sell S | 201 | $16.1K |
| Mar 4, 2026 | Joseph Baroldi 10b5-1 | Exercise M | 201 | $6.6K |
| Mar 4, 2026 | Joseph Baroldi 10b5-1 | Sell S | 238 | $19.0K |
| Mar 4, 2026 | Joseph Baroldi 10b5-1 | Exercise M | 238 | $13.5K |
| Mar 3, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 832 | $0 |
| Mar 3, 2026 | Joseph Loscalzo 10b5-1 | Sell S | 832 | $66.8K |
| Mar 3, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 832 | $31.7K |
| Mar 3, 2026 | Joseph Klein III 10b5-1 | Exercise M | 4.0K | $0 |
| Mar 3, 2026 | Joseph Klein III 10b5-1 | Exercise M | 12.0K | $0 |
| Mar 3, 2026 | Joseph Klein III 10b5-1 | Sell S | 1.0K | $81.8K |
| Mar 3, 2026 | Joseph Klein III 10b5-1 | Sell S | 6.8K | $543.5K |
| Mar 3, 2026 | Joseph Klein III 10b5-1 | Sell S | 13.5K | $1.1M |
| Mar 3, 2026 | Joseph Klein III 10b5-1 | Exercise M | 4.0K | $171.5K |
| Mar 3, 2026 | Joseph Klein III 10b5-1 | Exercise M | 12.0K | $480.6K |
| Mar 3, 2026 | Allene M. Diaz 10b5-1 | Exercise M | 10.3K | $0 |
| Mar 3, 2026 | Allene M. Diaz 10b5-1 | Exercise M | 18.0K | $0 |
| Mar 3, 2026 | Allene M. Diaz 10b5-1 | Exercise M | 12.0K | $0 |
| Mar 3, 2026 | Allene M. Diaz 10b5-1 | Sell S | 1.0K | $81.2K |
| Mar 3, 2026 | Allene M. Diaz 10b5-1 | Sell S | 14.6K | $1.2M |
| Mar 3, 2026 | Allene M. Diaz 10b5-1 | Sell S | 39.3K | $3.1M |
| Mar 3, 2026 | Allene M. Diaz 10b5-1 | Exercise M | 18.0K | $720.9K |
| Mar 3, 2026 | Allene M. Diaz 10b5-1 | Exercise M | 12.0K | $456.7K |
| Mar 3, 2026 | Allene M. Diaz 10b5-1 | Exercise M | 10.3K | $424.0K |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Exercise M | 385 | $0 |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Exercise M | 3.8K | $0 |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Exercise M | 3.5K | $0 |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Exercise M | 5.5K | $0 |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Exercise M | 7.0K | $0 |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Sell S | 755 | $61.0K |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Sell S | 5.0K | $402.4K |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Sell S | 14.3K | $1.1M |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Exercise M | 385 | $20.4K |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Exercise M | 7.0K | $226.6K |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Exercise M | 5.5K | $190.8K |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Exercise M | 3.8K | $153.6K |
| Mar 3, 2026 | Shannon L. Devers 10b5-1 | Exercise M | 3.5K | $131.9K |
| Mar 3, 2026 | Joseph Baroldi 10b5-1 | Exercise M | 820 | $0 |
| Mar 3, 2026 | Joseph Baroldi 10b5-1 | Exercise M | 879 | $0 |
| Mar 3, 2026 | Joseph Baroldi 10b5-1 | Sell S | 36 | $2.9K |
| Mar 3, 2026 | Joseph Baroldi 10b5-1 | Sell S | 2.1K | $167.9K |
| Mar 3, 2026 | Joseph Baroldi 10b5-1 | Exercise M | 879 | $28.7K |
| Mar 3, 2026 | Joseph Baroldi 10b5-1 | Exercise M | 820 | $46.6K |
| Mar 3, 2026 | Joseph Baroldi 10b5-1 | Sell S | 4.1K | $325.1K |
| Mar 3, 2026 | BENNETT C FRANK 10b5-1 | Exercise M | 48.6K | $0 |
| Mar 3, 2026 | BENNETT C FRANK 10b5-1 | Exercise M | 16.5K | $0 |
| Mar 3, 2026 | BENNETT C FRANK 10b5-1 | Sell S | 802 | $64.8K |
| Mar 3, 2026 | BENNETT C FRANK 10b5-1 | Sell S | 12.7K | $1.0M |
| Mar 3, 2026 | BENNETT C FRANK 10b5-1 | Sell S | 71.6K | $5.7M |
| Mar 3, 2026 | BENNETT C FRANK 10b5-1 | Exercise M | 48.6K | $3.0M |
| Mar 3, 2026 | BENNETT C FRANK 10b5-1 | Exercise M | 16.5K | $536.7K |
| Feb 27, 2026 | Eric Swayze | Other J | 256 | $12.5K |
| Feb 27, 2026 | O'NEIL PATRICK R. | Other J | 376 | $18.4K |
| Feb 27, 2026 | Brett P Monia KEY | Other J | 484 | $23.7K |
| Feb 27, 2026 | Brian Birchler | Other J | 351 | $17.2K |
| Feb 27, 2026 | BENNETT C FRANK | Other J | 261 | $12.8K |
| Feb 26, 2026 | Ludwig Hantson | Grant A | 3.2K | — |
| Feb 13, 2026 | Eric Swayze 10b5-1 | Sell S | 6.2K | $509.4K |
| Feb 13, 2026 | Eric Swayze 10b5-1 | Sell S | 9.4K | $769.5K |
| Feb 11, 2026 | Lynne B Parshall 10b5-1 | Sell S | 5.0K | $413.6K |
| Feb 6, 2026 | Brett P Monia KEY 10b5-1 | Sell S | 29.4K | $2.5M |
| Feb 2, 2026 | BENNETT C FRANK 10b5-1 | Exercise M | 48.6K | $0 |
| Feb 2, 2026 | BENNETT C FRANK 10b5-1 | Exercise M | 16.5K | $0 |
| Feb 2, 2026 | BENNETT C FRANK 10b5-1 | Sell S | 16.5K | $1.4M |
| Feb 2, 2026 | BENNETT C FRANK 10b5-1 | Exercise M | 16.5K | $536.7K |
| Feb 2, 2026 | BENNETT C FRANK 10b5-1 | Sell S | 48.6K | $4.0M |
| Feb 2, 2026 | BENNETT C FRANK 10b5-1 | Exercise M | 48.6K | $3.0M |
| Feb 2, 2026 | BENNETT C FRANK 10b5-1 | Sell S | 20.0K | $1.7M |
| Feb 2, 2026 | BENNETT C FRANK | Other J | 0 | $0 |
| Jan 30, 2026 | Eric Swayze | Sell S | 6.2K | $512.4K |
| Jan 30, 2026 | Eugene Schneider | Sell S | 6.2K | $515.6K |
| Jan 30, 2026 | O'NEIL PATRICK R. | Sell S | 6.2K | $516.2K |
| Jan 30, 2026 | Brett P Monia KEY | Sell S | 63.0K | $5.2M |
| Jan 30, 2026 | HOUGEN ELIZABETH L KEY | Sell S | 7.0K | $581.7K |
| Jan 30, 2026 | Brian Birchler | Sell S | 6.2K | $513.0K |
| Jan 30, 2026 | Joseph Baroldi | Sell S | 5.3K | $439.4K |
| Jan 30, 2026 | BENNETT C FRANK | Sell S | 5.9K | $488.1K |
| Jan 29, 2026 | Eric Swayze | Grant A | 12.0K | $0 |
| Jan 29, 2026 | Eugene Schneider | Grant A | 12.0K | $0 |
| Jan 29, 2026 | O'NEIL PATRICK R. | Grant A | 12.0K | $0 |
| Jan 29, 2026 | Brett P Monia KEY | Grant A | 122.2K | $0 |
| Jan 29, 2026 | HOUGEN ELIZABETH L KEY | Grant A | 13.6K | $0 |
| Jan 29, 2026 | Brian Birchler | Grant A | 12.0K | $0 |
| Jan 29, 2026 | Joseph Baroldi | Grant A | 10.3K | $0 |
| Jan 29, 2026 | BENNETT C FRANK | Grant A | 11.4K | $0 |
| Jan 22, 2026 | Shannon L. Devers 10b5-1 | Sell S | 4.0K | $323.5K |
| Jan 16, 2026 | Eric Swayze | Sell S | 49 | $3.7K |
| Jan 16, 2026 | Eric Swayze | Sell S | 9.9K | $744.7K |
| Jan 16, 2026 | Eugene Schneider | Sell S | 9.3K | $703.1K |
| Jan 16, 2026 | O'NEIL PATRICK R. | Sell S | 9.2K | $697.0K |
| Jan 16, 2026 | Brett P Monia KEY | Sell S | 44.0K | $3.3M |
| Jan 16, 2026 | Holly B. Kordasiewicz | Sell S | 4.1K | $313.3K |
| Jan 16, 2026 | Kyle Jenne | Sell S | 1.8K | $138.5K |
| Jan 16, 2026 | HOUGEN ELIZABETH L KEY | Sell S | 12.9K | $972.0K |
| Jan 16, 2026 | Shannon L. Devers | Sell S | 8.4K | $634.4K |
| Jan 16, 2026 | Brian Birchler | Sell S | 8.5K | $636.9K |
| Jan 16, 2026 | Joseph Baroldi | Sell S | 1.1K | $87.1K |
| Jan 16, 2026 | Joseph Baroldi | Sell S | 6.9K | $523.2K |
About IONS insider trading
This page tracks insider transactions for IONIS PHARMACEUTICALS INC (IONS) reported to the U.S. Securities and Exchange Commission on Form 4. Corporate insiders — directors, executive officers and beneficial owners of more than 10% of the stock — must disclose their trades within two business days. Open-market purchases (code P) and sales (code S) made at the insider's discretion are the most-watched opportunistic signals, while awards (A), option exercises (M) and tax-withholding (F) reflect compensation rather than conviction. Trades marked 10b5-1 were made under a pre-arranged plan and are considered routine. A cluster buy — several insiders buying within a short window — is historically a stronger bullish indicator than any single trade.