RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Insider

10% Owner

Trades at: TYRA· COAG· ACET· CDTX

30D 90D 1Y

Net shares · 90d

+4.2M

8.9M buy · 4.7M sell

Net value · 90d

$7.6M

$57.9M in · $50.2M out

Sentiment · 90d

Net buying

54% buying · 46% selling

Open-market trades · 90d

8.9M buy · 4.7M sell

Net buy / sell volume (all companies)

Tap or hover the chart for daily net volume. Green = net buying, red = net selling.

All transactions · open-market

Include grants & non-market

TYRA Sell·S
Jun 16, 26

10% Owner

$3.7K

9.9K sh · $0.37

Own -3%
TYRA Sell·S
Jun 16, 26

10% Owner

$51.7K

139.7K sh · $0.37

Own -3%
COAG Buy·P
Jun 16, 26

10% Owner

$1.5M

61.5K sh · $24.98

Own +1%
TYRA Sell·S
Jun 15, 26

10% Owner

$3.3K

8.6K sh · $0.39

Own -2%
TYRA Sell·S
Jun 15, 26

10% Owner

$46.9K

120.2K sh · $0.39

Own -2%
COAG Buy·P
Jun 15, 26

10% Owner

$153.0K

6.1K sh · $24.89

Own +0%
TYRA Sell·S
Jun 12, 26

10% Owner

$4.5K

11.3K sh · $0.40

Own -3%
TYRA Sell·S
Jun 12, 26

10% Owner

$63.6K

159.1K sh · $0.40

Own -3%
TYRA Sell·S
Jun 11, 26

10% Owner

$6.6K

17.4K sh · $0.38

Own -5%
TYRA Sell·S
Jun 11, 26

10% Owner

$93.1K

245.1K sh · $0.38

Own -5%
TYRA Sell·S
Jun 10, 26

10% Owner

$1.1K

3.1K sh · $0.37

Own -1%
TYRA Sell·S
Jun 10, 26

10% Owner

$15.9K

42.9K sh · $0.37

Own -1%
TYRA Sell·S
Jun 9, 26

10% Owner

$9.1K

24.6K sh · $0.37

Own -6%
TYRA Sell·S
Jun 9, 26

10% Owner

$127.7K

345.2K sh · $0.37

Own -6%
COAG Buy·P
May 20, 26

10% Owner

$24.8K

996 sh · $24.94

Own +0%
COAG Buy·P
May 19, 26

10% Owner

$94.9K

3.8K sh · $24.97

Own +0%
TYRA Sell·S
May 12, 26

10% Owner

$4.3K

6.7K sh · $0.64

Own -2%
TYRA Sell·S
May 12, 26

10% Owner

$60.4K

94.4K sh · $0.64

Own -2%
COAG Buy·P
May 12, 26

10% Owner

$159.0K

6.4K sh · $24.90

Own +0%
COAG Buy·P
May 11, 26

10% Owner

$643.0K

25.7K sh · $25.00

Own +0%
COAG Buy·P
May 11, 26

10% Owner

$346.2K

14.1K sh · $24.47

Own +0%
TYRA Sell·S
May 11, 26

10% Owner

$3.9K

5.8K sh · $0.67

Own -1%
TYRA Sell·S
May 11, 26

10% Owner

$54.7K

81.7K sh · $0.67

Own -1%
COAG Buy·P
May 8, 26

10% Owner

$37.0K

1.5K sh · $24.98

Own +0%
TYRA Sell·S
May 8, 26

10% Owner

$17.8K

25.0K sh · $0.71

Own -6%
TYRA Sell·S
May 8, 26

10% Owner

$249.6K

351.5K sh · $0.71

Own -6%
COAG Buy·P
May 7, 26

10% Owner

$49.5K

2.0K sh · $24.95

Own +0%
COAG Buy·P
May 7, 26

10% Owner

$192.8K

7.9K sh · $24.34

Own +0%
TYRA Sell·S
Apr 22, 26

Director, 10% Owner

$2.6M

165.2K sh · $15.77

Own -6%
TYRA Sell·S
Apr 20, 26

Director, 10% Owner

$2.7M

172.0K sh · $15.77

Own -6%
TYRA Sell·S
Apr 17, 26

Director, 10% Owner

$7.5M

458.4K sh · $16.28

Own -14%
TYRA Sell·S
Apr 15, 26

Director, 10% Owner

$858.8K

53.6K sh · $16.01

Own -2%
TYRA Sell·S
Apr 14, 26

Director, 10% Owner

$2.5M

153.7K sh · $15.97

Own -5%
TYRA Sell·S
Apr 13, 26

Director, 10% Owner

$8.6M

530.6K sh · $16.15

Own -13%
TYRA Sell·S
Apr 10, 26

Director, 10% Owner

$13.0K

828 sh · $15.75

Own -0%
TYRA Sell·S
Apr 9, 26

Director, 10% Owner

$2.2M

135.2K sh · $16.59

Own -3%
TYRA Sell·S
Apr 8, 26

Director, 10% Owner

$2.2M

130.9K sh · $16.91

Own -3%
TYRA Sell·S
Apr 8, 26

Director, 10% Owner

$5.8M

353.2K sh · $16.32

Own -8%
TYRA Sell·S
Apr 6, 26

Director, 10% Owner

$125.3K

6.8K sh · $18.50

Own -0%
TYRA Sell·S
Apr 6, 26

Director, 10% Owner

$774.2K

44.7K sh · $17.31

Own -1%
TYRA Sell·S
Apr 6, 26

Director, 10% Owner

$8.9M

537.8K sh · $16.51

Own -10%
TYRA Sell·S
Apr 2, 26

Director, 10% Owner

$29.1K

1.5K sh · $19.06

Own -0%
TYRA Sell·S
Apr 2, 26

Director, 10% Owner

$4.7M

258.5K sh · $18.23

Own -5%
TYRA Buy·P
Mar 30, 26

Director, 10% Owner

$6.3M

971.1K sh · $6.50

Own +4%
TYRA Buy·P
Mar 27, 26

Director, 10% Owner

$16.0M

2.5M sh · $6.43

Own +11%
TYRA Buy·P
Mar 26, 26

Director, 10% Owner

$2.2M

351.2K sh · $6.38

Own +2%
TYRA Buy·P
Mar 26, 26

Director, 10% Owner

$30.0M

5.0M sh · $6.06

Own +27%

Date▾	Ticker	Role	Type	Shares	Own Δ	Price	Value
Jun 16, 2026	TYRA	10% Owner	Sell S	9.9K	-3%	$0.37	$3.7K
Jun 16, 2026	TYRA	10% Owner	Sell S	139.7K	-3%	$0.37	$51.7K
Jun 16, 2026	COAG	10% Owner	Buy P	61.5K	+1%	$24.98	$1.5M
Jun 15, 2026	TYRA	10% Owner	Sell S	8.6K	-2%	$0.39	$3.3K
Jun 15, 2026	TYRA	10% Owner	Sell S	120.2K	-2%	$0.39	$46.9K
Jun 15, 2026	COAG	10% Owner	Buy P	6.1K	+0%	$24.89	$153.0K
Jun 12, 2026	TYRA	10% Owner	Sell S	11.3K	-3%	$0.40	$4.5K
Jun 12, 2026	TYRA	10% Owner	Sell S	159.1K	-3%	$0.40	$63.6K
Jun 11, 2026	TYRA	10% Owner	Sell S	17.4K	-5%	$0.38	$6.6K
Jun 11, 2026	TYRA	10% Owner	Sell S	245.1K	-5%	$0.38	$93.1K
Jun 10, 2026	TYRA	10% Owner	Sell S	3.1K	-1%	$0.37	$1.1K
Jun 10, 2026	TYRA	10% Owner	Sell S	42.9K	-1%	$0.37	$15.9K
Jun 9, 2026	TYRA	10% Owner	Sell S	24.6K	-6%	$0.37	$9.1K
Jun 9, 2026	TYRA	10% Owner	Sell S	345.2K	-6%	$0.37	$127.7K
May 20, 2026	COAG	10% Owner	Buy P	996	+0%	$24.94	$24.8K
May 19, 2026	COAG	10% Owner	Buy P	3.8K	+0%	$24.97	$94.9K
May 12, 2026	TYRA	10% Owner	Sell S	6.7K	-2%	$0.64	$4.3K
May 12, 2026	TYRA	10% Owner	Sell S	94.4K	-2%	$0.64	$60.4K
May 12, 2026	COAG	10% Owner	Buy P	6.4K	+0%	$24.90	$159.0K
May 11, 2026	COAG	10% Owner	Buy P	25.7K	+0%	$25.00	$643.0K
May 11, 2026	COAG	10% Owner	Buy P	14.1K	+0%	$24.47	$346.2K
May 11, 2026	TYRA	10% Owner	Sell S	5.8K	-1%	$0.67	$3.9K
May 11, 2026	TYRA	10% Owner	Sell S	81.7K	-1%	$0.67	$54.7K
May 8, 2026	COAG	10% Owner	Buy P	1.5K	+0%	$24.98	$37.0K
May 8, 2026	TYRA	10% Owner	Sell S	25.0K	-6%	$0.71	$17.8K
May 8, 2026	TYRA	10% Owner	Sell S	351.5K	-6%	$0.71	$249.6K
May 7, 2026	COAG	10% Owner	Buy P	2.0K	+0%	$24.95	$49.5K
May 7, 2026	COAG	10% Owner	Buy P	7.9K	+0%	$24.34	$192.8K
Apr 22, 2026	TYRA	Director, 10% Owner	Sell S	165.2K	-6%	$15.77	$2.6M
Apr 20, 2026	TYRA	Director, 10% Owner	Sell S	172.0K	-6%	$15.77	$2.7M
Apr 17, 2026	TYRA	Director, 10% Owner	Sell S	458.4K	-14%	$16.28	$7.5M
Apr 15, 2026	TYRA	Director, 10% Owner	Sell S	53.6K	-2%	$16.01	$858.8K
Apr 14, 2026	TYRA	Director, 10% Owner	Sell S	153.7K	-5%	$15.97	$2.5M
Apr 13, 2026	TYRA	Director, 10% Owner	Sell S	530.6K	-13%	$16.15	$8.6M
Apr 10, 2026	TYRA	Director, 10% Owner	Sell S	828	-0%	$15.75	$13.0K
Apr 9, 2026	TYRA	Director, 10% Owner	Sell S	135.2K	-3%	$16.59	$2.2M
Apr 8, 2026	TYRA	Director, 10% Owner	Sell S	130.9K	-3%	$16.91	$2.2M
Apr 8, 2026	TYRA	Director, 10% Owner	Sell S	353.2K	-8%	$16.32	$5.8M
Apr 6, 2026	TYRA	Director, 10% Owner	Sell S	6.8K	-0%	$18.50	$125.3K
Apr 6, 2026	TYRA	Director, 10% Owner	Sell S	44.7K	-1%	$17.31	$774.2K
Apr 6, 2026	TYRA	Director, 10% Owner	Sell S	537.8K	-10%	$16.51	$8.9M
Apr 2, 2026	TYRA	Director, 10% Owner	Sell S	1.5K	-0%	$19.06	$29.1K
Apr 2, 2026	TYRA	Director, 10% Owner	Sell S	258.5K	-5%	$18.23	$4.7M
Mar 30, 2026	TYRA	Director, 10% Owner	Buy P	971.1K	+4%	$6.50	$6.3M
Mar 27, 2026	TYRA	Director, 10% Owner	Buy P	2.5M	+11%	$6.43	$16.0M
Mar 26, 2026	TYRA	Director, 10% Owner	Buy P	351.2K	+2%	$6.38	$2.2M
Mar 26, 2026	TYRA	Director, 10% Owner	Buy P	5.0M	+27%	$6.06	$30.0M

About RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

This profile aggregates every SEC Form 4 insider transaction reported by RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah across all companies they trade. Open-market purchases (code P) and sales (code S) are the highest-signal, discretionary trades; grants (A), option exercises (M) and gifts (G) reflect compensation rather than conviction and carry no market price. Figures cover the selected period and update as new filings are ingested.