SYRE
insider transactionsSpyre Therapeutics, Inc. — buys & sells by directors, officers and 10% owners A shareholder owning more than 10% of the company. Must report trades, but usually a weaker signal than an officer or director. (SEC Form 4).
Net shares · 90d
-247.1K
0 buy · 247.1K sell
Net value · 90d
-$17.2M
$0 in · $17.2M out
Sentiment · 90d
Net selling
0% buying · 100% selling
Open-market trades · 90d
30
0 buy · 247.1K sell
Net buy / sell volume
Not enough data to chart yet.
Tap or hover the chart for daily net volume. Green = net buying, red = net selling.
All transactions
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Exercise·M
Chief Medical Officer · 10b5-1
$0
8.3K sh
Own +3%
-
Sell·S
Chief Medical Officer · 10b5-1
$625.0K
8.3K sh · $75.00
Own -100%
-
Exercise·M
Chief Medical Officer · 10b5-1
$228.8K
8.3K sh · $27.46
Own New
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$235.1K
3.3K sh · $71.38
Own -1%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$574.5K
8.1K sh · $70.50
Own -1%
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Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$246.9K
3.6K sh · $69.40
Own -1%
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Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$0
7.5K sh
Own +2%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$223.4K
3.1K sh · $72.06
Own -3%
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Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$183.9K
2.6K sh · $70.77
Own -3%
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Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$125.6K
1.8K sh · $69.75
Own -2%
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Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$108.8K
7.5K sh · $14.50
Own +8%
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Grant·A
Director
$0
8.0K sh
Own New
-
Grant·A
Director
$0
8.0K sh
Own New
-
Grant·A
Director
$0
8.0K sh
Own New
-
Grant·A
Director
$0
8.0K sh
Own New
-
Grant·A
Director
$0
8.0K sh
Own New
-
Sell·S
Director · 10b5-1
$1.5M
19.3K sh · $75.35
Own -18%
-
Sell·S
Director · 10b5-1
$1.9M
24.8K sh · $74.76
Own -19%
-
Sell·S
Director · 10b5-1
$2.5M
33.5K sh · $73.72
Own -20%
-
Sell·S
Director · 10b5-1
$174.5K
2.4K sh · $72.57
Own -1%
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Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$22.5K
300 sh · $74.96
Own -0%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$126.2K
1.7K sh · $74.23
Own -0%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$226.7K
3.1K sh · $73.14
Own -1%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$71.8K
1.0K sh · $71.76
Own -0%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$254.8K
3.6K sh · $70.77
Own -1%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$368.6K
5.3K sh · $69.54
Own -1%
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Exercise·M
Chief Medical Officer · 10b5-1
$0
78.3K sh
Own +32%
-
Sell·S
Chief Medical Officer · 10b5-1
$30.1K
400 sh · $75.37
Own -100%
-
Sell·S
Chief Medical Officer · 10b5-1
$377.4K
5.1K sh · $74.60
Own -93%
-
Sell·S
Chief Medical Officer · 10b5-1
$763.8K
10.4K sh · $73.74
Own -65%
-
Sell·S
Chief Medical Officer · 10b5-1
$932.0K
12.8K sh · $72.94
Own -45%
-
Sell·S
Chief Medical Officer · 10b5-1
$628.1K
8.8K sh · $71.56
Own -23%
-
Sell·S
Chief Medical Officer · 10b5-1
$1.4M
19.7K sh · $70.61
Own -34%
-
Sell·S
Chief Medical Officer · 10b5-1
$1.5M
21.3K sh · $69.53
Own -27%
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Exercise·M
Chief Medical Officer · 10b5-1
$2.2M
78.3K sh · $27.46
Own New
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$0
12.5K sh
Own +3%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$892.1K
12.5K sh · $71.37
Own -11%
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$181.2K
12.5K sh · $14.50
Own +13%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$132.6K
2.7K sh · $49.92
Own -0%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$607.3K
12.3K sh · $49.20
Own -2%
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Exercise·M
Chief Medical Officer · 10b5-1
$0
8.0K sh
Own +10%
-
Sell·S
Chief Medical Officer · 10b5-1
$397.9K
8.0K sh · $50.00
Own -100%
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Exercise·M
Chief Medical Officer · 10b5-1
$172.4K
8.0K sh · $21.66
Own New
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$0
7.5K sh
Own +2%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$65.0K
1.3K sh · $49.98
Own -1%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$305.1K
6.2K sh · $49.21
Own -6%
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$108.8K
7.5K sh · $14.50
Own +8%
| Date▾ | Insider | Type | Shares | Value |
|---|---|---|---|---|
| Jun 3, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 8.3K | $0 |
| Jun 3, 2026 | Sheldon Sloan 10b5-1 | Sell S | 8.3K | $625.0K |
| Jun 3, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 8.3K | $228.8K |
| Jun 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 3.3K | $235.1K |
| Jun 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 8.1K | $574.5K |
| Jun 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 3.6K | $246.9K |
| Jun 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 7.5K | $0 |
| Jun 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 3.1K | $223.4K |
| Jun 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 2.6K | $183.9K |
| Jun 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 1.8K | $125.6K |
| Jun 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 7.5K | $108.8K |
| May 27, 2026 | Laurie Stelzer | Grant A | 8.0K | $0 |
| May 27, 2026 | Sandra Milligan | Grant A | 8.0K | $0 |
| May 27, 2026 | Mark C. Mckenna | Grant A | 8.0K | $0 |
| May 27, 2026 | Michael Thomas Henderson | Grant A | 8.0K | $0 |
| May 27, 2026 | Jeffrey W. Albers | Grant A | 8.0K | $0 |
| May 8, 2026 | Michael Thomas Henderson 10b5-1 | Sell S | 19.3K | $1.5M |
| May 8, 2026 | Michael Thomas Henderson 10b5-1 | Sell S | 24.8K | $1.9M |
| May 8, 2026 | Michael Thomas Henderson 10b5-1 | Sell S | 33.5K | $2.5M |
| May 8, 2026 | Michael Thomas Henderson 10b5-1 | Sell S | 2.4K | $174.5K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 300 | $22.5K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 1.7K | $126.2K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 3.1K | $226.7K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 1.0K | $71.8K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 3.6K | $254.8K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 5.3K | $368.6K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 78.3K | $0 |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 400 | $30.1K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 5.1K | $377.4K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 10.4K | $763.8K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 12.8K | $932.0K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 8.8K | $628.1K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 19.7K | $1.4M |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 21.3K | $1.5M |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 78.3K | $2.2M |
| May 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 12.5K | $0 |
| May 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 12.5K | $892.1K |
| May 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 12.5K | $181.2K |
| Apr 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 2.7K | $132.6K |
| Apr 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 12.3K | $607.3K |
| Apr 1, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 8.0K | $0 |
| Apr 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 8.0K | $397.9K |
| Apr 1, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 8.0K | $172.4K |
| Apr 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 7.5K | $0 |
| Apr 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 1.3K | $65.0K |
| Apr 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 6.2K | $305.1K |
| Apr 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 7.5K | $108.8K |
About SYRE insider trading
This page tracks insider transactions for Spyre Therapeutics, Inc. (SYRE) reported to the U.S. Securities and Exchange Commission on Form 4. Corporate insiders — directors, executive officers and beneficial owners of more than 10% of the stock — must disclose their trades within two business days. Open-market purchases (code P) and sales (code S) made at the insider's discretion are the most-watched opportunistic signals, while awards (A), option exercises (M) and tax-withholding (F) reflect compensation rather than conviction. Trades marked 10b5-1 were made under a pre-arranged plan and are considered routine. A cluster buy — several insiders buying within a short window — is historically a stronger bullish indicator than any single trade.